Hypolipidemic and Antihyperlipidemic Effects of Holarrhena pubescens Methanolic Extract Is Mediated through Inhibition of Lipase Activity and Lipid Accumulation

Holarrhena pubescens seeds are used in the treatment of various diseases, especially diabetes and associated complications, different parts world. The present study was undertaken to determine hypolipidemic antihyperlipidemic effects methanolic extract H. rats. subjected LC-MS analysis chemical constituents. action studied by determining effect 28-day oral administration seed on serum cholesterol, triglycerides, HDL-cholesterol levels. rats fed with a high-fat diet containing cholesterol saturated fat, same lipid parameters were estimated during treatment. To elucidate its probable mechanism action, vitro studies inhibition accumulation preadipocytes, DPP-IV inhibitory effect, lipase enzyme studied. reduced levels triglycerides both normal animals without significant highly effective inhibiting activity but showed modest DPP-IV. results demonstrated that has mediated probably through activity.